Untangling the ErbB signalling network

Yosef Yarden; MX Sliwkowski

doi:10.1038/35052073

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Journal article

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Untangling the ErbB signalling network

Yosef Yarden and MX Sliwkowski

Nature Reviews Molecular Cell Biology, Vol.2(2), pp.127-137

Feb/2001

DOI: https://doi.org/10.1038/35052073

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Abstract

When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over 25,000 women with breast cancer have now been treated with trastuzumab (Herceptin(R)), a recombinant antibody designed to block the receptor ErbB2. Likewise, small-molecule enzyme inhibitors and monoclonal antibodies to ErbB1 are in advanced phases of clinical testing. What can this pathway teach us about translating basic science into clinical use?

Details

Title: Untangling the ErbB signalling network
Creators: Yosef Yarden (null) - The Weizmann Institute of Science
MX Sliwkowski (null)
Resource Type: Journal article; Review
Publication Details: Nature Reviews Molecular Cell Biology, Vol.2(2), pp.127-137; Feb/2001
Number of pages: 11
Language: English
DOI: https://doi.org/10.1038/35052073
Record Identifier: 993262281003596

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